4.7 Review

Recent Advances in the Synthesis of Spiro-β-Lactams and Spiro-δ-Lactams

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Review Chemistry, Organic

Synthesis of Lactams via Isocyanide-Based Multicomponent Reactions

Shrikant G. Pharande

Summary: This review summarizes strategies for the synthesis of alpha-, beta-, gamma-, delta- and epsilon-lactams using isocyanide-based multicomponent reactions (IMCRs) or IMCRs/post-transformation reactions reported in the literature between 2000 and 2020. Lactams are important heterocycles found in a wide range of bioactive molecules, natural products and drugs, leading to significant efforts in developing efficient synthesis methods. Despite their versatility in various fields of chemistry, there has been no dedicated review on IMCRs concerning lactam synthesis, highlighting the importance of this review.

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[2+1+1] Assembly of spiro β-lactams by Rh(ii)-catalyzed reaction of diazocarbonyl compounds with azirines/isoxazoles

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Guowei Kang et al.

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Highly Diastereo- and Enantioselective Synthesis of α-Spiro-δ-lactams by an Organocascade Reaction

Kaiheng Zhang et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2017)

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Synthesis of some novel indeno[1,2-b]quinoxalin spiro-β-lactam conjugates

Javad Ameri Rad et al.

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Palladium-Catalyzed, Multicomponent Approach to β-Lactams via Aryl Halide Carbonylation

Gerardo M. Torres et al.

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Enantioselective Synthesis of (+)-Peganumine A

Cyril Piemontesi et al.

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Tosylimidazole-mediated one-pot synthesis of 2-azetidinones

Saleheh Zavar et al.

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Yogesh Kumar et al.

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Jianguang Liu et al.

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Facile synthesis of β-lactam derivatives by the Staudinger reaction using 3,6-dichlorotetrazine

Maaroof Zarei et al.

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Diazo- and Transition-Metal-Free C-H Insertion: A Direct Synthesis of β-Lactams

Luis F. R. Gomes et al.

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A General and Efficient Method to Access Tetracyclic Spirooxindole Derivatives

Abderrahman El Bouakher et al.

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Synthesis of α-Methylene-β-Lactams via PPh3-Catalyzed Umpolung Cyclization of Propiolamides

Lin Zhu et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

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Phosphine Organocatalysis for the Synthesis of Spirocyclic Compounds

Arnaud Voituriez et al.

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An efficient synthesis of spiro- β-lactams having sulfenyl, sulfinyl and sulfonyl moiety

Reshma et al.

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The use of spirocyclic scaffolds in drug discovery

Yajun Zheng et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

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Cody Ross Pitts et al.

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Michal Szostak et al.

CHEMICAL REVIEWS (2013)

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Recent Trends in the Design, Synthesis and Biological Exploration of β-Lactams

G. Veinberg et al.

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CHEMICAL SOCIETY REVIEWS (2012)

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Recent Advances in the Synthesis of α-Alkylidene-Substituted δ-Lactones, γ-Lactams and δ-Lactams

Anna Albrecht et al.

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Synthesis and reactivity of spiro-fused β-lactams

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TETRAHEDRON (2011)

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Selected Synthetic Strategies to Spirocyclics

Sambasivarao Kotha et al.

SYNTHESIS-STUTTGART (2009)

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Preparation of β-lactams by [2+2] cycloaddition of ketenes and imines

Nanyan Fu et al.

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Origin of the relative stereoselectivity of the β-lactam formation in the Staudinger reaction

Lei Jiao et al.

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