Lipid composition optimization in spray congealing technique and testing with curcumin-loaded microparticles

Spray-congealing, a technique based on the fast solidification of sprayed molten lipids, is considered a novel strategy to encapsulate natural products. Among others, it is a safe, low cost, fast and reproducible technique, with rising interest for several applications (e.g. food applications). One of the key parameters for the application of this technique is the lipid solidification temperature, which can be modulated by optimizing the lipid composition. In this work, three lipid components (beeswax, carnauba wax, and medium-chain triglycerides (Miglyol 812)) were selected, and the mixture composition modelled using a simplex-centroid experimental design. Three different lipid compositions were chosen to validate the proposed model, then tested in the preparation of curcumin-loaded microparticles (1.5%, w/w). The pro-duced microparticles were analysed in terms of colour, morphology, particle size, encapsulation effi-ciency and load, physicochemical, crystalline, and thermal properties. Results evidenced that microparticle's properties, including encapsulation efficiency, vary according to the used lipid mixture, supporting their tailoring role. This fact brings advantages in the design of microencapsulation systems based on spray congealing processes, broadening their applicability. Moreover, lipid composition optimi-sation was proved to be an important tool to precede the development of spray-congealing applications. (c) 2021 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.

Automated summary

Spray-congealing is a novel strategy for encapsulating natural products, offering benefits such as safety, low cost, speed, and reproducibility. Research has shown that the properties of microparticles vary depending on the lipid mixture used, emphasizing the importance of lipid composition optimization in the design of microencapsulation systems.