期刊
ADVANCED MATERIALS
卷 33, 期 24, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202100425
关键词
brain tumors; cancer treatment; high‐ energy photons; light‐ responsive nanoparticles; microneedles
类别
资金
- Institute for Basic Science [IBS-R006-D1, IBS-R006-A1]
- National Research Foundation (NRF) of Korea [NRF-2017M3D1A1039288]
- Ministry of Science & ICT (MSIT), Republic of Korea [IBS-R006-D1-2021-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2017M3D1A1039288] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study proposed a method for localized delivery of theranostic nanoparticles and high-energy photons to target tumors using microneedles-on-bioelectronics system. The integration of microneedles and bioelectronics enables the targeted delivery of theranostic nanoparticles and effective transmission of high-energy photons for tumor treatment.
The low delivery efficiency of light-responsive theranostic nanoparticles (NPs) to target tumor sites, particularly to brain tumors due to the blood-brain barrier, has been a critical issue in NP-based cancer treatments. Furthermore, high-energy photons that can effectively activate theranostic NPs are hardly delivered to the target region due to the strong scattering of such photons while penetrating surrounding tissues. Here, a localized delivery method of theranostic NPs and high-energy photons to the target tumor using microneedles-on-bioelectronics is presented. Two types of microneedles and flexible bioelectronics are integrated and mounted on the edge of surgical forceps. Bioresorbable microneedles containing theranostic NPs deliver the NPs into target tumors (e.g., glioblastoma, pituitary adenoma). Magnetic resonance imaging can locate the NPs. Then, light-guiding/spreading microneedles deliver high-energy photons from bioelectronics to the NPs. The high-energy photons activate the NPs to treat tumor tissues by photodynamic therapy and chemotherapy. The controlled thermal actuation by the bioelectronics accelerates the diffusion of chemo-drugs. The proposed method is demonstrated with mouse tumor models in vivo.
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