期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 27, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202101297
关键词
activated photothermal therapy; COX‐ 2 inhibitors; H; S-2 responsive; intracellular bottom‐ up synthesis; ultrasmall CuS nanodots
类别
资金
- National Key R&D Program of China [2018YFA0903500]
- Postdoctoral Science Fund of China [2017M622429]
- Max Planck Partner Group
A new treatment strategy involving Cu-meloxicam complexes encapsulated by human serum albumin for intracellular bottom-up synthesis of CuS nanodots has been developed, which effectively eliminates tumors and inhibits inflammation induced by photothermal damage. The therapy demonstrates promising results for precise cancer treatment.
The clinical application of photothermal therapy (PTT) is limited by the accuracy of thermal damage and the risk of tumor metastasis and relapse induced by hyperthermia-related inflammation. Intracellular bottom-up synthesis (iBuS) of CuS nanoparticles from small-molecule precursors inside tumor cells triggered by tumor specific stimuli is a promising strategy to enhance the precision of PTT treatment and reduce the risk of nondegradable metal nanoparticles. Herein, monolocking nanoparticles (MLNPs) with Cu-meloxicam complexes encapsulated by human serum albumin (HSA) are reported, which efficiently form CuS nanodots via the elevated concentration of endogenous H2S inside tumor cells and meanwhile release meloxicam for anti-inflammatory effects. The intracellular bottom-up fabrication of CuS nanodots is directly visualized by TEM. An enhanced PTT effect is observed with 4T1 cells caused by additional meloxicam-induced inactivation of the COX-2 enzyme. After systemic administration, MLNPs completely ablate tumors under laser exposure, simultaneously inhibiting the inflammation induced by photothermal damage, and can be cleared via the kidney into urine. This strategy provides a new route for activated multimodal therapy, which could be applicable to precisely combat cancer.
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