期刊
ADVANCED ENGINEERING MATERIALS
卷 23, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adem.202100322
关键词
biomaterials; carbon nanotubes; endovascular embolization; intracranial aneurysms; shape memory polymers
资金
- Oklahoma Shared Clinical and Translational Resources (OSCTR) Pilot Projects Program (NIGMS) [U54GM104938]
- Oklahoma Center for the Advancement of Science and Technology (OCAST) Health Research Program [HR18-002]
- VPRP Office
- Institute for Biomedical Engineering, Science and Technology (IBEST) at the University of Oklahoma
- Alumni Fellowship from the Graduate College at the University of Oklahoma
This study investigates the infiltration of carbon nanotubes in polyurethane SMP foam to design electrically triggered embolic devices for intracranial aneurysms. The results show that CNTs can reduce the glass transition temperature of the SMP and alter its mechanical properties, providing a promising approach for individualized treatment of aneurysms. Furthermore, the study demonstrates the Joule-heating triggering for SMP shape recovery in endovascular therapy applications.
Current endovascular therapies for intracranial aneurysms face limitations that include aneurysm recurrence and incomplete occlusion. These challenges can potentially be addressed by occluding the aneurysm space with shape memory polymers (SMPs) that are tailorable to patient-specific aneurysm geometries to improve the suboptimal treatment outcomes associated with coil embolization. However, deployment of the SMP-based device into the aneurysm requires external stimuli to trigger shape recovery. Thus, herein, the infiltration of carbon nanotubes (CNTs) in a polyurethane SMP foam is investigated, and Joule-heating triggering for SMP shape recovery in endovascular therapy applications is demonstrated. The results show that CNTs can be successfully infiltrated in the SMP foam, providing tunable resistivity and shape recovery time, and that CNT infiltration reduces the glass transition temperature of the SMP and alters its mechanical properties, which is evidenced with a cumulative stress reduction in cyclic compression tests. Finally, the Joule-heating capability of the SMP material is examined using a proof-of-concept in vitro occlusion experiment of an idealized saccular aneurysm model. Collectively, this study indicates that CNT infiltration of SMP foams is a promising approach in the design of electrically triggered embolic devices for individualized treatment of intracranial aneurysms.
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