期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 171, 期 -, 页码 164-186出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.01.022
关键词
COVID-19; Cutaneous immunobiology; Infectious diseases; Microarray patches; Prophylactic immunization; Skin-targeted vaccines; SARS-CoV-2; Spike protein
资金
- Institute for Infection, Inflammation, and Immunity in Children (i4Kids)
- NIH [UM1-AI106701, R01-AR074285, R01-AR071277]
- UPMC Enterprises [IPA 25565]
The COVID-19 pandemic poses a serious threat to global health and economy. The development of a safe and effective vaccine is crucial for combating infectious pathogens, and the skin's accessible microenvironment is considered an ideal target for vaccination.
The COVID-19 pandemic is a serious threat to global health and the global economy. The ongoing race to develop a safe and efficacious vaccine to prevent infection by SARS-CoV-2, the causative agent for COVID-19, highlights the importance of vaccination to combat infectious pathogens. The highly accessible cutaneous microenvironment is an ideal target for vaccination since the skin harbors a high density of antigen-presenting cells and immune accessory cells with broad innate immune functions. Microarray patches (MAPs) are an attractive intracutaneous biocargo delivery system that enables safe, reproducible, and controlled administration of vaccine components (antigens, with or without adjuvants) to defined skin microenvironments. This review describes the structure of the SARS-CoV-2 virus and relevant antigenic targets for vaccination, summarizes key concepts of skin immunobiology in the context of prophylactic immunization, and presents an overview of MAP-mediated cutaneous vaccine delivery. Concluding remarks on MAP-based skin immunization are provided to contribute to the rational development of safe and effective MAP-delivered vaccines against emerging infectious diseases, including COVID-19. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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