期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 175, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.05.001
关键词
Immune contexture; Tumor models; Organoids; Immune checkpoint inhibitors; Tumor microenvironment
资金
- National University of Singapore [R-397-000-343-133]
- National Medical Research Council Young Individual Research Grant (NMRC YIRG) [MOH-000136]
- Ministry of Education Academic Research Fund Tier 1 Grant
- National Cancer Centre Cancer Fund
- National Medical Research Council Clinician Scientist Award - Senior Investigator (NMRC CSA-SI) [MOH-000325-00]
This review discusses the parameters that influence the induction of different immune contextures within tumors and how engineering strategies can be utilized to develop the next generation of immune-competent patient-derived in vitro models.
In the past decade, immune checkpoint inhibitors (ICI) have proven to be tremendously effective for a subset of cancer patients. However, it is difficult to predict the response of individual patients and efforts are now directed at understanding the mechanisms of ICI resistance. Current models of patient tumors poorly recapitulate the immune contexture, which describe immune parameters that are associated with patient survival. In this Review, we discuss parameters that influence the induction of different immune contextures found within tumors and how engineering strategies may be leveraged to recapitulate these contextures to develop the next generation of immune-competent patient-derived in vitro models. (c) 2021 Elsevier B.V. All rights reserved.
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