期刊
ACTA OTO-LARYNGOLOGICA
卷 141, 期 5, 页码 537-543出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016489.2021.1891456
关键词
Hypopharyngeal squamous cell carcinoma; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; derived neutrophil-to-lymphocyte ratio; overall survival; recurrence-free survival
资金
- project of invigorating Health Care through Science, Technology and Education [ZDXKB2016015]
- Medical Science and technology development Foundation, Nanjing Department of Health [YKK18081]
- Jiangsu Provincial key research and development [BE2018605]
This study retrospectively assessed the effects of platelet-lymphocyte ratio (PLR) on recurrence-free survival (RFS) and overall survival (OS) in patients undergoing radical resection for advanced hypopharyngeal squamous cell carcinoma (HSCC). Elevated PLR was found to be associated with an increased risk of recurrence and reduced survival in these cases. Further multi-institutional prospective studies are needed to better understand the prognostic value of pre-operative blood PLR in HSCC.
Background Patient prognosis in hypopharyngeal carcinoma remains difficult to predict, necessitating new, readily available biomarkers. Objective Platelet-lymphocyte ratio (PLR)'s effects on recurrence-free survival (RFS) and overall survival (OS) were evaluated in individuals undergoing radical resection for advanced hypopharyngeal squamous cell carcinoma (HSCC). Methods A total of 89 patients were retrospectively assessed. PLR, and derived neutrophil-lymphocyte (dNLR) and neutrophil-lymphocyte (NLR) ratios were determined based on complete blood count. Then, the prognostic values of PLR, dNLR and NLR were assessed by univariate and multivariate Cox regression analyses adjusted for disease-specific prognostic factors. Endpoints of interest were RFS and OS. Results The optimal cutoff of PLR was 98.815, based on which individuals were categorized into the high- (PLR >= 98.815) and low- (PLR <98.815) PLR groups. High PLR (p = .022) had a significant association with reduced RFS, which still showed significance in multivariable analysis (HR = 2.020, 95%CI: 1.076-3.794, p = .029). In univariate analysis, PLR (p = .046) and positive surgical margin (p = .021) also had significant associations with OS. Conclusion Elevated PLR has associations with increased risk of recurrence and reduced survival in advanced HSCC cases undergoing radical resection. High presurgical PLR may independently predict RFS. Therefore, further multi-institutional prospective studies are needed to better characterize the role of pre-operative blood PLR as prognostic factors in HSCC.
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