期刊
ACTA ONCOLOGICA
卷 60, 期 6, 页码 727-734出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/0284186X.2021.1891280
关键词
Nestin; CD34; colorectal cancer; tumor microenvironment; hypoxia associated immune response
类别
资金
- SNF (CH) [310030_149745]
- Swiss National Science Foundation [PZ00P3_168165]
In colorectal cancer patients, high expression of nestin and CD34 in the tumor stroma is associated with better prognosis, possibly by modulating a favorable immune response. Additionally, the high expression of nestin and CD34 is correlated with lower vascular invasion and improved 5-year overall survival.
Background Nestin, a class VI intermediate filament protein of the cytoskeleton, and CD34, a transmembrane phosphoglycoprotein, are markers of progenitor cells. This study aimed to evaluate their expression and clinical significance in colorectal cancer. Methods A clinically annotated tissue microarray, including 599 patients with colorectal cancer, was analyzed by immunohistochemistry. Furthermore, nestin and CD34 correlations with HIF-1a and a panel of cytokines and chemokines were assessed using quantitative reverse transcription PCR and The Cancer Genome Atlas dataset. Results Expression of nestin and CD34 was observed only in the tumor stroma. Patients displaying high expression of nestin and CD34 demonstrated higher rates of T1 and T2 tumors (p = .020), lower vascular invasion (p < .001) and improved 5-year overall survival (65%; 95% CI = 55-73 vs 45%; 95% CI = 37-53) after adjusting for clinicopathological characteristics (HR: 0.67; 95% CI = 0.46-0.96). A moderate to strong correlation (r = 0.37-0.78, p < .03) of nestin and CD34 was demonstrated for the following markers; HIF-1 alpha, CD4, CD8, FOXP3, IRF1, GATA3, CCL2, CCL3, CXCL12 and CCL21. Conclusions Combined expression of nestin and CD34 expression is associated with better overall survival possibly by modulating a favorable immune response.
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