期刊
ACS NANO
卷 15, 期 4, 页码 6326-6339出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c05792
关键词
biomimicry; nanoparticles; cancer; inflammation; microfluidics
类别
资金
- NCI [F31CA232705]
- Office of Women's Health [1R56CA213859]
- NIH Ruth L. Kirschstein Research Service Award [F31CA232705]
- Cancer Prevention Institute of Texas [RP170466]
- Kleberg Foundation
The study demonstrated that by adjusting the protein content ratio, biomimetic nanoparticles were able to effectively target inflamed endothelium, showing potential for improving treatment of inflammatory-based conditions through targeted nanodelivery.
Biomimetic nanoparticles aim to effectively emulate the behavior of either cells or exosomes. Leukocyte-based biomimetic nanoparticles, for instance, incorporate cell membrane proteins to transfer the natural tropism of leukocytes to the final delivery platform. However, tuning the protein integration can affect the in vivo behavior of these nanoparticles and alter their efficacy. Here we show that, while increasing the protein:lipid ratio to a maximum of 1:20 (w/w) maintained the nanoparticle's structural properties, increasing protein content resulted in improved targeting of inflamed endothelium in two different animal models. Our combined use of a microfluidic, bottom-up approach and tuning of a key synthesis parameter enabled the synthesis of reproducible, enhanced biomimetic nanoparticles that have the potential to improve the treatment of inflammatory-based conditions through targeted nanodelivery.
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