期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 20, 页码 24095-24105出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c02089
关键词
carboxymethyl chitosan; hydrogel; trivalent ions; self-healing; wound dressing
资金
- Key Research and Development Program of Hubei Province [2020BCA079]
- National Natural Science Foundation of China [81871493]
- Fundamental Research Funds for the Central Universities
A new type of injectable CMCh hydrogel wound dressing with self-healing properties is constructed using coordination bonds and alkali/urea aqueous solutions. The hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability, significantly accelerating skin tissue regeneration and wound closure. It has great potential in tissue engineering applications.
Herein, a new type of injectable carboxymethyl chitosan (CMCh) hydrogel wound dressing with self-healing properties is constructed. First, CMCh samples are homogeneously synthesized in alkali/urea aqueous solutions. Subsequently, trivalent metal ions of Fe3+ and Alyy3+ are introduced to form coordination bonds with CMCh, leading to an ultrafast gelation process. A series of hydrogels can be obtained by altering the concentration of CMCh and the relative content of metal ions. Owing to the dynamic and reversible characteristics of the coordination bonds, the hydrogel exhibits self-healing, self-adaption, and thermoresponsive ability. Moreover, due to the interaction between the amino groups on CMCh and SO42-, the hydrogel undergoes phase separation and can be painlessly detached from the skin with little residue. Taking advantage of all these characteristics, the hydrogel is used as a wound dressing and can significantly accelerate skin tissue regeneration and wound closure. This hydrogel has great potential in the application of tissue engineering.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据