期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 13, 页码 14985-14994出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c01337
关键词
multifunctional biomaterials; bioactive glass nanoparticles; fetal bovine serum; tumor therapy; bioimaging
资金
- National Natural Science Foundation of China [51872224, 51802227]
- Special Support Program for High Level Talents of Shaanxi Province [7122200063]
- Wenzhou Science and Technology Bureau Project [ZY2019003, Y20190123, Y2020236]
- Medical Health Science and Technology Project of Zhejiang Province [2019KY464]
The study developed FBS-decorated EuBGN nanoparticles with excellent biosafety and enhanced tumor targeting for cancer imaging and therapy, showing great potential in future cancer treatment.
Multifunctional nanocarriers with a simple structure and biocompatibility for bioimaging, potential tumor targeting, and precise antitumor ability are promising in cancer therapy. Bioactive glass is an important biomaterial and has been used in clinical bone tissue repair due to the high biocompatibility and bioactivity. Herein, we report fetal bovine serum (FBS)-decorated europium-doped bioactive glass nanoparticles (EuBGN@FBS) with excellent biosafety and enhanced tumor targeting for cancer imaging and therapy. EuBGN@FBS showed the controlled photoluminescent properties and pH-responsive anticancer drug release behavior. The FBS decoration significantly enhanced the dispersibility in physiological medium and improved hemocompatibility and cellular uptake of EuBGN. Relative to EuBGN, EuBGN@FBS could also efficiently image the cancer cell and show significantly enhanced targeted tumor imaging and chemotherapy in vivo while retaining negligible side effects. The simple and biocompatible structure with efficient tumor targeting, imaging, and therapy makes EuBGN@FBS highly promising in future cancer therapy.
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