期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 14, 页码 15992-16006出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c21938
关键词
postlaparotomy adhesion; antiadhesion; carboxymethyl cellulose; hydrogel; thermosensitive; biomaterials; biopolymers
资金
- National Research Foundation (NRF) grant - Korean Government (MIST) [2019R1A4A1024116, 2018R1D1A1A09083269]
- National Research Foundation of Korea [2019R1A4A1024116, 2018R1D1A1A09083269] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study developed biocompatible and biodegradable antiadhesion agents with excellent physical characteristics and stability, showing high effectiveness in preventing postlaparotomy adhesion; in SD rat experiments, they were more effective than the traditional Medicurtain, demonstrating great potential in reducing complications during clinical surgeries.
Pharmacological-based treatment approaches have been used over time to prevent postlaparotomy adhesion. However, the rapid elimination of therapeutics from the peritoneum, and their unwanted side effects, easy flow from the wound site by gravity, and low therapeutic efficacy increase the urgent need for the next generation of antiadhesion agents. This article represents the development of biocompatible and biodegradable antiadhesion agents that consist of carboxymethyl cellulose (CMC) and pullulan with three different types of physical characteristics such as the solution type (ST), film type (FT), and thermosensitive type (TST). These antiadhesion agents that contain no drugs exhibit excellent physical characteristics and superior stability over 30 days in the operative sites without any toxicity and side effects that make the compositions strong candidates as novel antiadhesion agents. Also, the proposed samples reveal superior antiadhesion and tissue regeneration properties in Sprague-Dawley (SD) rats after surgery over Medicurtain. Medicurtain effectively prevented postlaparotomy adhesion in similar to 42% of experimental animals, whereas ST 2.25-10, ST 2.5-5, ST 2.5-10, FT 20, and TST 1.5 were effective in 100% of animals. Thus, we believe these antiadhesion agents could be promising to reduce adhesion-related complications during and post-surgical operations and deserve consideration for further study for clinical purposes.
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