期刊
LIFE-BASEL
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/life11030231
关键词
oligodendrocytes; glia; myelin; neuron; myelination; multiple sclerosis
资金
- ARSEP [R20218DD]
- Brain Paris Institute
- INSERM
- Funds for research, University of Lausanne, Switzerland
- ANR [JC R17127DD]
- Biogen
Multiple sclerosis is a complex inflammatory disease of the central nervous system characterized by neurodegeneration and demyelination. Understanding the mechanisms of remyelination is crucial for promoting neuroprotection and limiting disease progression. The interaction between neurons and the oligodendroglial lineage plays a significant role in potential therapeutic strategies for supporting remyelination and neuroprotection in MS.
Multiple sclerosis (MS) is a complex central nervous system inflammatory disease leading to demyelination and associated functional deficits. Though endogenous remyelination exists, it is only partial and, with time, patients can enter a progressive phase of the disease, with neurodegeneration as a hallmark. Though major therapeutic advances have been made, with immunotherapies reducing relapse rate during the inflammatory phase of MS, there is presently no therapy available which significantly impacts disease progression. Remyelination has been shown to favor neuroprotection, and it is thus of major importance to better understand remyelination mechanisms in order to promote them and hence preserve neurons. A crucial point is how this process is regulated through the neuronal crosstalk with the oligodendroglial lineage. In this review, we present the current knowledge on neuron interaction with the oligodendroglial lineage, in physiological context as well as in MS and its experimental models. We further discuss the therapeutic possibilities resulting from this research field, which might allow to support remyelination and neuroprotection and thus limit MS progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据