期刊
LIFE-BASEL
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/life11030189
关键词
autophagy; ocular pathology; glaucoma; cataract; diabetic retinopathy; AMD
资金
- Ophthalmological Network OFTARED (Enfermedades oculares: Prevencion, deteccion precoz, tratamiento y rehabilitacion de las patologias oculares) of the Institute of Health of Carlos III of the Spanish Ministry of Economy [RD16/0008/0005, RD16/0008/0026]
- European programme FEDER
- Network RETiBRAIN (La retina un modelo para investigar Neuroproteccion en patologias del Sistema Nervioso Central) of Spanish Ministry of Science and Innovation [RED2018-102499-T]
- Spanish Ministry of Science, Innovation, and Universities [FPU17/01023]
- Complutense University of Madrid [CT42/18-CT43/18]
Autophagy is a crucial process for maintaining cell homeostasis in the eyes, especially in protecting against oxidative damage. Ocular pathologies are often influenced by factors such as age and oxidative stress, which directly impact the autophagy activity. Interruption of autophagy processes can lead to the accumulation of cellular debris and physiological dysfunction in the eyes.
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.
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