期刊
PHARMACEUTICALS
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ph14020149
关键词
miR-7; multidrug resistance; cancer
资金
- National Science Centre [2018/29/B/NZ3/02642]
- Centre of Postgraduate Education [506-1-025-01-20]
MiR-7 is a well-studied miRNA that plays a significant role in cancer progression and MDR modulation, potentially serving as an adjuvant agent to enhance the efficiency of standard chemotherapeutics.
MicroRNAs (miRNAs, miRs) are small non-coding RNA (ncRNA) molecules capable of regulating post-transcriptional gene expression. Imbalances in the miRNA network have been associated with the development of many pathological conditions and diseases, including cancer. Recently, miRNAs have also been linked to the phenomenon of multidrug resistance (MDR). MiR-7 is one of the extensively studied miRNAs and its role in cancer progression and MDR modulation has been highlighted. MiR-7 is engaged in multiple cellular pathways and acts as a tumor suppressor in the majority of human neoplasia. Its depletion limits the effectiveness of anti-cancer therapies, while its restoration sensitizes cells to the administered drugs. Therefore, miR-7 might be considered as a potential adjuvant agent, which can increase the efficiency of standard chemotherapeutics.
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