期刊
PHARMACEUTICALS
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ph14020133
关键词
anticancer drug; drug design; metal-based drug; monofunctional platinum complex
资金
- National Natural Science Foundation of China [31570809, 21877059, 21731004, 91953201]
- Natural Science Foundation of Jiangsu Province [BK20202004]
- Key Scientific Research Project of Colleges and Universities in He'nan Province [21A150009]
Monofunctional platinum(II) complexes are a class of non-traditional anticancer agents hopeful to overcome the defects of current platinum drugs, with designs aiming to visualize cellular distribution, reduce side effects, improve tumor selectivity, or inhibit cancer cells through non-DNA targets.
Platinum-based anticancer drugs represented by cisplatin play important roles in the treatment of various solid tumors. However, their applications are largely compromised by drug resistance and side effects. Much effort has been made to circumvent the drug resistance and general toxicity of these drugs. Among multifarious designs, monofunctional platinum(II) complexes with a general formula of [Pt(3A)Cl](+) (A: Ammonia or amine) stand out as a class of non-traditional anticancer agents hopeful to overcome the defects of current platinum drugs. This review aims to summarize the development of monofunctional platinum(II) complexes in recent years. They are classified into four categories: fluorescent complexes, photoactive complexes, targeted complexes, and miscellaneous complexes. The intention behind the designs is either to visualize the cellular distribution, or to reduce the side effects, or to improve the tumor selectivity, or inhibit the cancer cells through non-DNA targets. The information provided by this review may inspire researchers to conceive more innovative complexes with potent efficacy to shake off the drawbacks of platinum anticancer drugs.
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