期刊
JOURNAL OF HEPATOCELLULAR CARCINOMA
卷 8, 期 -, 页码 35-44出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JHC.S290197
关键词
HCC; local ablation therapy; oligometastasis; propensity score matching
类别
资金
- Dong-A research fund [2018-31-0904]
This study found that local therapy for oligometastatic lesions in patients with hepatocellular carcinoma can significantly improve survival rates and progression-free survival rates. Factors such as lower alpha-fetoprotein levels and the use of local therapy were identified as significant favorable prognostic factors.
Purpose: With respect to various solid cancers, patients with oligometastasis may benefit from local therapy. However, this approach is not widely accepted for hepatocellular carcinoma. This study investigated the efficacy of local therapy for oligometastatic lesions in patients with hepatocellular carcinoma. Patients and Methods: The study included 69 hepatocellular carcinoma patients presenting with oligometastasis to the lung. Characteristics of the patients and treatment options for metastatic lesions were reviewed, and a survival analysis was performed. After propensity score matching, overall survival and progression-free survival were calculated from the time of pulmonary metastasis detection. Factors predicting prognosis were analyzed using a multivariate Cox regression analysis. Results: After propensity score matching, 58 patients with Child-Pugh grade A disease were selected. Among them, 22 patients were treated with systemic therapy alone while 36 patients received local therapy or a combination of local and systemic therapies for metastatic lesions. Survival rates were higher in patients receiving local therapy than in those receiving systemic therapy (2-year overall survival rate, 66.6 vs 31.2%, p<0.001, 2-year progression-free survival rate, 47.0 vs 10.6%, p=0.005). In the multivariate Cox regression analysis, alpha-fetoprotein levels less than 400 ng/mL and the use of local therapy for metastatic lesions were found to be significant favorable prognostic factors. Conclusion: Local therapy for metastatic lesions improved the oncologic outcomes of patients with hepatocellular carcinoma with pulmonary oligometastasis.
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