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Immunomodulatory Role of Urolithin A on Metabolic Diseases

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Summary: Comparative studies were conducted on the effects of urolithin A, iso-urolithin A, and urolithin B, as well as their glucuronides, on processes associated with the inflammatory response. Urolithin A was found to be the most active metabolite in inhibiting the inflammatory response, while the glucuronide conjugates were not effective in this regard. Phase II metabolism was shown to diminish the pharmacological properties of urolithins.

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