期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 23, 期 10, 页码 9852-9861出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-016-6153-z
关键词
Glyphosate; Melanomacrophages; Melanin; Hemosiderin; Morphological responses; Genotoxic effects
资金
- CONICET [PIP 0723]
- FAPESP [2013/02067-5]
- CNPq [306123/2012-6]
- Universidad Nacional de San Luis [109/11 CS]
- [FAPESP 2014/00946-4]
Glyphosate (GLY) is the most used herbicide worldwide and its effects on anurans are well known. Pollutants can cause physiological and morphological effects. Therefore, this study evaluated the effects of GLY on hepatic melanomacrophages as a response to environmental stressors. Three treatments were exposed to different concentrations of pure GLY (100, 1000, and 10,000 mu g g(-1), respectively), and there was also a control group. After the experimental time, liver and blood were analyzed. Melanomacrophages (MMCs) were located between the hepatocyte cordons, close to sinusoids. GLY increased the melanin area in MMCs of Leptodactylus latinasus exposed since lowest concentration until highest concentration. GLY also changed the occurrence of hepatic catabolism pigments into melanomacrophages and erythrocyte nuclear abnormalities; therefore, it can interfere with the hepatic metabolism. In conclusion, GLY promotes alterations in the hepatic tissue and erythrocyte nuclear abnormalities. Furthermore, MMCs may be useful as morphological responses of GLY effects.
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