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Formulation-based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives

期刊

出版社

WILEY
DOI: 10.1002/btm2.10215

关键词

antigens; dermatological diseases; nanocarriers; nucleic acids; siRNA; transcutaneous vaccination

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  1. John A Paulson School of Engineering & Applied Sciences at Harvard University

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The advantages of dermal delivery of biomacromolecules include improved targetability, reduced systemic toxicity, and decreased degradation of drugs, while the main challenge lies in the barrier function of the skin. Current research is focused on improving the delivery of macromolecules to the skin using noninvasive methods, such as nucleic acids and antigens.
A growing variety of biological macromolecules are in development for use as active ingredients in topical therapies and vaccines. Dermal delivery of biomacromolecules offers several advantages compared to other delivery methods, including improved targetability, reduced systemic toxicity, and decreased degradation of drugs. However, this route of delivery is hampered by the barrier function of the skin. Recently, a large body of research has been directed toward improving the delivery of macromolecules to the skin, ranging from nucleic acids (NAs) to antigens, using noninvasive means. In this review, we discuss the latest formulation-based efforts to deliver antigens and NAs for vaccination and treatment of skin diseases. We provide a perspective of their advantages, limitations, and potential for clinical translation. The delivery platforms discussed in this review may provide formulation scientists and clinicians with a better vision of the alternatives for dermal delivery of biomacromolecules, which may facilitate the development of new patient-friendly prophylactic and therapeutic medicines.

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