期刊
NPJ PARKINSONS DISEASE
卷 7, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41531-021-00155-0
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资金
- National Key R&D Program of China [2018YFA0701400]
- National Natural Science Foundation of China [61673346, 81520108010]
- National Major Scientific Instruments Development Project of China [81527901]
- Science and Technology Project of Zhejiang Province [2016C34006]
- Fundamental Research Funds for the Central Universities [2019XZZX001-01-21]
- Zhejiang Lab [2018EB0ZX01]
- Zhejiang University 7T Brain Imaging Research Center
The study found that PD patients have a more severe PVS burden in the basal ganglia and midbrain, with the PVS number in the basal ganglia significantly correlated to disease severity and medication dosage. Additionally, there may be potential correlations between PVS burden and both grey and white matter microstructures.
Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on Parkinson's disease (PD) remains unclear. We aimed to investigate the clinical and neuroimaging significance of PVS in basal ganglia (BG) and midbrain in early-stage PD. We recruited 40 early-stage PD patients and 41 healthy controls (HCs). Both PVS number and volume were calculated to evaluate PVS burden on 7 T magnetic resonance imaging images. We compared PVS burden between PD and HC, and conducted partial correlation analysis between PVS burden and clinical and imaging features. PD patients had a significantly more serious PVS burden in BG and midbrain, and the PVS number in BG was significantly correlated to the PD disease severity and L-dopa equivalent dosage. The fractional anisotropy and mean diffusivity values of certain subcortical nuclei and white matter fibers within or nearby the BG and midbrain were significantly correlated with the ipsilateral PVS burden indexes. Regarding to the midbrain, the difference between bilateral PVS burden was, respectively, correlated to the difference between fiber counts of white fiber tract passing through bilateral substantia nigra in PD. Our study suggests that PVS burden indexes in BG are candidate biomarkers to evaluate PD motor symptom severity and aid in predicting medication dosage. And our findings also highlight the potential correlations between PVS burden and both grey and white matter microstructures.
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