期刊
BIOACTIVE MATERIALS
卷 6, 期 3, 页码 836-879出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.09.013
关键词
Biocorrosion; Biodegradable metals; Tissue engineering; Zinc-based alloys and composites
资金
- Australian Research Council (ARC) [DP170102557]
- ARC Future Fellowship [FT160100252]
Biodegradable metals (BMs) are gradually degrading in vivo, with magnesium-based BMs undergoing the most clinical trials, iron-based BMs exhibiting slower degradation rates, and zinc-based BMs considered a new class with intermediate degradation rates. Further research is needed to validate the suitability of zinc-based BMs for biomedical applications.
Biodegradable metals (BMs) gradually degrade in vivo by releasing corrosion products once exposed to the physiological environment in the body. Complete dissolution of biodegradable implants assists tissue healing, with no implant residues in the surrounding tissues. In recent years, three classes of BMs have been extensively investigated, including magnesium (Mg)-based, iron (Fe)-based, and zinc (Zn)-based BMs. Among these three BMs, Mg-based materials have undergone the most clinical trials. However, Mg-based BMs generally exhibit faster degradation rates, which may not match the healing periods for bone tissue, whereas Fe-based BMs exhibit slower and less complete in vivo degradation. Zn-based BMs are now considered a new class of BMs due to their intermediate degradation rates, which fall between those of Mg-based BMs and Fe-based BMs, thus requiring extensive research to validate their suitability for biomedical applications. In the present study, recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs. The underlying roles of alloy composition, microstructure, and processing technique on the mechanical and corrosion properties of Zn-based BMs are also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据