期刊
BIOACTIVE MATERIALS
卷 6, 期 3, 页码 794-809出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.09.009
关键词
Cyanine conjugate; Cancer theranostics; Therapeutic agent; Nanocarrier; Clinical translation
资金
- National Key Research and Development Program of China [2016YFA0201400]
- State Key Program of National Natural Science of China [81930047]
- Projects of International Cooperation and Exchanges NSFCPSF [31961143003]
- National Project for Research and Development of Major Scientific Instruments [81727803]
- Beijing Natural Science Foundation, Haidian, original innovation joint fund [17L20170]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421004]
This review summarizes the applications of various cyanine-therapeutic agent conjugates in cancer theranostics, covering different therapeutic modalities and analyzing their potential for clinical translation.
Cyanine is a meritorious fluorogenic core for the construction of fluorescent probes and its phototherapeutic potential has been enthusiastically explored as well. Alternatively, the covalent conjugation of cyanine with other potent therapeutic agents not only boosts its therapeutic efficacy but also broadens its therapeutic modality. Herein, we summarize miscellaneous cyanine-therapeutic agent conjugates in cancer theranostics from literature published between 2014 and 2020. The application scenarios of such theranostic cyanine conjugates covered common cancer therapeutic modalities, including chemotherapy, phototherapy and targeted therapy. Besides, cyanine conjugates that serve as nanocarriers for drug delivery are introduced as well. In an additional section, we analyze the potential of these conjugates for clinical translation. Overall, this review is aimed to stimulate research interest in exploring unattempted therapeutic agents and novel conjugation strategies and hopefully, accelerate clinical translation in this field.
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