期刊
BIOACTIVE MATERIALS
卷 6, 期 2, 页码 346-360出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.08.016
关键词
Poly(lactic-co-glycolic acid); Composite organic-inorganic biomaterial; Bone-substitute material; Bone tissue engineering; Bone regeneration
资金
- National Natural Science Foundation of China [51973216, 51873207, 51803006, 51833010]
- Science and Technology Development Program of Jilin Province [20200404182YY]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2019005]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology) [2020-KF-5]
This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.
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