期刊
NPJ 2D MATERIALS AND APPLICATIONS
卷 5, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41699-021-00202-7
关键词
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资金
- Brain Pool Program (NRF) - Ministry of Science and ICT [2019H1D3A2A02102086]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2020R1A6A1A06046235]
- National Research Foundation of Korea (NRF) - (MSIT) [2020R1A2C1009463]
- National Research Foundation of Korea [2020R1A2C1009463, 2019H1D3A2A02102086] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The GO-aptamer conjugate materials show great promise for cancer diagnostics and therapy, serving as an effective alternative to antibody-based strategies. Additionally, GO’s excellent fluorescence quenching properties can be harnessed for efficient fluorescence-sensing platforms in detecting major cancer biomarkers.
2D graphene oxide (GO) with large surface area, multivalent structure can easily bind single-stranded DNA/RNA (aptamers) through hydrophobic/pi-stacking interactions, whereas aptamers having small size, excellent chemical stability and low immunogenicity bind to their targets with high affinity and specificity. GO-aptamer conjugate materials synthesized by integrating aptamers with GO can thus provide a better alternative to antibody-based strategies for cancer diagnostic and therapy. Moreover, GO's excellent fluorescence quenching properties can be utilized to develop efficient fluorescence-sensing platforms. In this review, recent advances in GO-aptamer conjugate materials for the detection of major cancer biomarkers have been discussed.
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