期刊
RISK MANAGEMENT AND HEALTHCARE POLICY
卷 14, 期 -, 页码 1033-1039出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/RMHP.S219294
关键词
malaria; vaccine; pre-erythrocytic; RTS,S; RTS,S/AS01; WHO; circumsporozoite
The RTS,S/AS01 vaccine is safe and immunogenic in children, but has modest efficacy against clinical malaria and requires a booster dose for improved protection. Its cost-effectiveness and potential public health impact are being assessed for wider deployment.
Background: Recent advances in mosquito eradication and antimalarial treatments have reduced the malaria burden only modestly. An effective malaria vaccine remains a high priority, but its development has several challenges. Among many potential candidates, the RTS,S/AS01 vaccine (MosquirixTM) remains the leading candidate. Objective and Method: This review aims to understand the advances in the RTS,S/AS01 vaccine, and future comments regarding the vaccine's effectiveness in malaria eradication. Literature review for the past five decades was performed searching PubMed, EMBASE Ovid, and Cochrane Library, with using the following search items: (malaria OR WHO's malaria OR Plasmodium falciparum OR RTS,S OR RTS,S/AS01 OR RTS,S/AS02 OR pre-erythrocytic malaria OR circumsporozoite OR Mosquirix) AND (vaccine OR vaccination). Results: RTS,S/AS01, a recombinant pre-erythrocytic vaccine containing Plasmodium falciparum surface-protein (circumsporozoite) antigen, is safe, well-tolerated, and immunogenic in children. Three doses, along with a booster, have a modest efficacy of about 36% in children (age 5-17 months) and about 26% in infants (age 6-12 weeks) against clinical malaria during a 48-month follow-up. However, the efficacy varies among population subgroups and with the parasite strain, it reduces without a booster and offers protection for a limited duration. Because of its potential cost-effectiveness and positive public health effect, the vaccine is being investigated in a pilot program for mortality benefits and broader deployment. Conclusion: The RTS,S/AS01 vaccine prevents malaria; however, it should be considered another addition to the malaria-control program and not as an eradication tool because of its relatively low to modest efficacy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据