期刊
DIAGNOSTICS
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics11020243
关键词
Kingella kingae; preterm premature rupture of membrane; Chorioamnionitis undifferentiated connective tissue disease
K. kingae is a Gram-negative coccobacillus that can cause septic arthritis in children and endocarditis in adults. This study presents a case of intrauterine fetal death due to K. kingae infection, which is a rare occurrence in acute chorioamnionitis leading to preterm rupture of membranes and miscarriage.
Kingella kingae is a Gram-negative coccobacillus belonging to the Neisseriaceae family. In children less than 4 years old, K. kingae invasive infection can induce septic arthritis and osteomyelitis, and more rarely endocarditis, meningitis, ocular infections, and pneumonia. In adults, it may be a cause of endocarditis. To date, K. kingae acute chorioamnionitis (AC) leading to preterm rupture of membranes (PPROM) and miscarriage has never been reported. Herein, we describe a case of intrauterine fetal death (IUFD) at 22 weeks' gestation due to K. kingae infection occurred in a patient affected by undifferentiated connective tissue disease (UCTD) in lupus erythematosus systemic (LES) evolution with severe neutropenia. K. kingae was isolated in placental subamnionic swab and tissue cultures as well as fetal ear, nose, and pharyngeal swabs. Placental histological examination showed necrotizing AC and funisitis. In the fetus, neutrophils were observed within the alveoli and in the gastrointestinal lumen. Maternal medical treatment for UCTD was modified according to the K. kingae invasive infection. In the event of IUFD due to AC, microbiological cultures on placenta and fetal tissues should always be carried out in order to isolate the etiologic agent and target the correct medical treatment.
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