期刊
PLANTS-BASEL
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/plants10020308
关键词
Arabidopsis thaliana; Viridiplantae; GCN5; ADA2b; SGF29; ADA3; plant development; plant stress responses; SAGA; histone acetylation
资金
- European Structural and Investment Funds (ESIF)
- Hellenic Republic Ministry of Development and Investments, Partnership Agreement (PA)
- Human Resources Development, Education and Lifelong Learning [103, 99073]
The translated content describes the formation of a pre-initiation complex during the transcription process of protein-encoding genes and the transcription factors required to activate gene expression. It mentioned how the SAGA complex modulates chromatin structure through acetylation and other histone modifications, and the specificity of GCN5 as a HAT for histone H3.
Transcription of protein-encoding genes starts with forming a pre-initiation complex comprised of RNA polymerase II and several general transcription factors. To activate gene expression, transcription factors must overcome repressive chromatin structure, which is accomplished with multiprotein complexes. One such complex, SAGA, modifies the nucleosomal histones through acetylation and other histone modifications. A prototypical histone acetyltransferase (HAT) known as general control non-repressed protein 5 (GCN5), was defined biochemically as the first transcription-linked HAT with specificity for histone H3 lysine 14. In this review, we analyze the components of the putative plant SAGA complex during plant evolution, and current knowledge on the biological role of the key components of the HAT module, GCN5 and ADA2b in plants, will be summarized.
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