期刊
BRAIN SCIENCES
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/brainsci11020200
关键词
glioma; glioblastoma; supratotal resection; 5-ALA; microglia; microRNA; extracellular vesicle; mTOR; immunomodulation
The composition and molecular signatures of the glioma core and infiltrative margins differ, with the tumor edge enriched in microglia. Microglia in HGGs play a dual role, with activation in M1 phenotype exhibiting a scavenger-tumoricidal role, while activation in M2 phenotype favoring tumor growth and infiltration. Modulation of microglia-glioma cross-talk may lead to more effective therapies.
Cellular composition and molecular signatures of the glioma core compared with infiltrative margins are different, and it is well known that the tumor edge is enriched in microglia. In this review of the literature, we summarize the role of the peritumoral area in high-grade gliomas (HGGs) from surgical and biological points of view. There is evidence on the dual role of microglia in HGGs-a scavenger-tumoricidal role when microglia are activated in an M1 phenotype and a role favoring tumor growth and infiltration/migration when microglia are activated in an M2 phenotype. Microglia polarization is mediated by complex pathways involving cross-talk with glioma cells. In this scenario, extracellular vesicles and their miRNA cargo seem to play a central role. The switch to a specific phenotype correlates with prognosis and the pathological assessment of a specific microglial setting can predict a patient's outcome. Some authors have designed an engineered microglial cell as a biologically active vehicle for the delivery of intraoperative near-infrared fluorescent dye with the aim of helping surgeons detect peritumoral infiltrated areas during resection. Furthermore, the pharmacological modulation of microglia-glioma cross-talk paves the way to more effective therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据