Toxicological Evaluation of Piceatannol, Pterostilbene, and ε-Viniferin for Their Potential Use in the Food Industry: A Review

The application of stilbenes in the food industry is being considered because of their biological activities. Piceatannol, pterostilbene and epsilon-viniferin have awakened the industry's interest. However, before they can be commercialized, we must first guarantee their safety for consumers. The present work reviews the toxicological studies performed with these stilbenes. A wide variety of studies has demonstrated their cytotoxic effects in both cancer and non-cancerous cell lines. In contrast, although DNA damage was detected by some authors, in vitro genotoxic studies on the effects of piceatannol, pterostilbene, and epsilon-viniferin remain scarce. None of the three reviewed substances have been evaluated using the in vitro tests required by the European Food Safety Authority (EFSA) as the first step in genotoxicity testing. We did not find any study on the toxic effects of these stilbenes in vivo. Thus, more studies are needed to confirm their safe use before they can be authorized as additive in the food industry.

Automated summary

The application of stilbenes in the food industry is gaining attention for their biological activities. However, the safety of compounds like piceatannol, pterostilbene, and epsilon-viniferin needs to be confirmed before commercialization. Studies have shown cytotoxic effects, but in vitro genotoxic studies are lacking, and in vivo tests are also needed for authorization as food additives.