期刊
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
卷 23, 期 20, 页码 20151-20167出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-016-7463-x
关键词
Workers; Chromium; Occupational setting; Oxidative stress; Cr toxicity
资金
- Hundred Talents Program of Chinese Academy of Sciences
- Key Application and Development Program of Chongqing Science and Technology Commission [cstc2014yykfC20004]
- HEC Start Up Research grant, Pakistan [21-700/SRGP/RD/HEC/2016]
- Chinese Academy of Sciences
The present review focused on the levels and toxicological status of heavy metals especially chromium (Cr) in the exposed workers from different occupational settings around the globe and in Pakistan. It was found that exposed workers from leather tanning and metal plating units showed elevated levels of Cr than the workers from other occupational settings. Cr and other heavy metals level in biological matrices of the exposed workers in different occupational settings revealed that developing countries are severely contaminated. Occupational settings from the Sialkot district, Pakistan exhibited elevated level of Cr in biological entities of the exposed workers. Review suggested that higher level of Cr exposure to the workers enhance the oxidative stress (reactive oxygen species (ROS) and hydroxyl (OH) radical generation) which may cause; cellular and molecular damage such as genotoxicity and chromosomal aberration formations, and carcinogenic effects. This review will help to understand the Cr contamination mechanisms and associated health implications in different occupational settings around the globe in general and particularly to Pakistan. This study will also assist occupational health and safety management authorities to devise or change the Cr recommended exposure limits (REL) for different occupational settings.
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