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Worms, Fat, and Death: Caenorhabditis elegans Lipid Metabolites Regulate Cell Death

期刊

METABOLITES
卷 11, 期 2, 页码 -

出版社

MDPI
DOI: 10.3390/metabo11020125

关键词

apoptosis; ferroptosis; polyunsaturated fatty acids

资金

  1. National Institutes of Health, National Institute of General Medical Sciences [R01GM133883]

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Caenorhabditis elegans is a key organism for studying genetic pathways underlying regulated cell death, particularly apoptosis. Research in C. elegans has also shown the roles of lipids in apoptosis and the induction of ferroptosis. This review highlights recent work in C. elegans regarding the roles of various lipids in regulated cell death.
Caenorhabditis elegans is well-known as the model organism used to elucidate the genetic pathways underlying the first described form of regulated cell death, apoptosis. Since then, C. elegans investigations have contributed to the further understanding of lipids in apoptosis, especially the roles of phosphatidylserines and phosphatidylinositols. More recently, studies in C. elegans have shown that dietary polyunsaturated fatty acids can induce the non-apoptotic, iron-dependent form of cell death, ferroptosis. In this review, we examine the roles of various lipids in specific aspects of regulated cell death, emphasizing recent work in C. elegans.

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