期刊
PATHOGENS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10030310
关键词
onchocerciasis-associated epilepsy; cerebrospinal fluid; cytokines
类别
资金
- European Research Council [ERC 671055]
This study did not find any cytokine significantly associated with onchocerciasis-associated epilepsy (OAE), although a lower IL-13 level was observed in the cerebrospinal fluid of OAE patients compared to African controls. The observed cytokine profiles and neuro-inflammation may be attributed to long-standing epilepsy, concurrent infections, and malnutrition. Ideally, cytokine levels should be prospectively determined in serum and cerebrospinal fluid collected at the onset of the first seizures.
Neuro-inflammation may be associated with onchocerciasis-associated epilepsy (OAE) but thus far very few immunological studies have been performed in children with this form of epilepsy. In a pilot study we measured the cytokine levels in cerebrospinal fluid (CSF) of persons with OAE from Maridi, South Sudan, and from Mosango, Democratic Republic of the Congo (DRC) and compared these results with cytokine levels in CSF of Africans with non-OAE neurological disorders, and Europeans with epilepsy or other neurological conditions. The following cytokines were studied: IL-6, TNF-alpha, IL1-beta, IL-5, IL-4, IL-13, CCL3 (Mip-1 alpha), VEGF-C, VCAM-1. No cytokine was significantly associated with OAE, although a lower IL-13 level was observed in CSF of persons with OAE compared to African controls. Observed cytokine profiles and neuro-inflammation may be the consequence of long-standing epilepsy, concomitant infections and malnutrition. Ideally cytokine levels should be determined in a prospective study in serum and CSF collected at the time of onset of the first seizures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据