期刊
PATHOGENS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pathogens10020213
关键词
Streptococcus suis serotype 28; Streptococcus suis serotype 31; characterization; genome; antibiotic resistance
类别
资金
- National Natural Science Foundation of China [31801662]
- National Key R&D Program of China [2019YFD0901702]
- Local Social Science Project [2018QD0031]
- Heilongjiang pig Modern Agricultural Technology Collaborative Innovation System
S. suis causes disease in pigs and is increasingly implicated in human disease worldwide. This study sequenced the genomes of multidrug-resistant S. suis serotype 28 and 31 strains. Different strains displayed varying pathogenicity in mouse infection models and harbored different resistance genes.
Streptococcus suis causes disease in pigs and is implicated increasingly in human disease worldwide. Although most clinical cases are associated with serotype 2, infections by other serotypes have sometimes been reported. Here, we sequenced the genome of a multidrug-resistant S. suis serotype 28 (strain 11313) and a multidrug-resistant S. suis serotype 31 (strain 11LB5). Strain 11313 was apathogenic in mouse infection models, whereas strain 11LB5 displayed ganglion demyelination, meningeal thickening, congestion, mononuclear cell infiltration, massive proliferation of cortical glial cells, and bacteria (>10(4) CFU/g) in the spinal cord and ganglia in mice. Furthermore, immunohistochemistry found that the heavily infiltrated glial cells were astrocytes. Strain 11313 harbored the resistance genes ant(6)-Ia, erm(B), optrA, tet(l), tet(o), and strain 11LB5 harbored the resistance genes ant(6)-Ia, erm(B), tet(40), tet(o/w/32/o), aac(6')-aph(2 ''). Mouse studies showed that strain 11LB5 exhibited a similar virulence to serotype 2 strain 700794, highlighting the need for surveillance of the other serotype S. suis isolates, in addition to serotype 2, in farms. This is the first report of the aminoglycoside resistance gene ant(6)-Ia in S. suis from animals. This suggests that S. suis might serve as an antibiotic resistance reservoir, which spreads the resistance gene ant(6)-Ia or optrA to other streptococcal pathogens on farms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据