期刊
MICROORGANISMS
卷 9, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms9020386
关键词
AI-2; chemotaxis; aggregation; biofilm; motility; Escherichia coli
类别
资金
- National Research Foundation of Korea (NRF) grant from the Korean government [NRF-2020R1F1A1072397]
AI-2, a ubiquitous metabolite, has been shown to influence biofilm formation and motility in Escherichia coli, establishing it as a true signal with important physiological roles. Additionally, AI-2 signaling in E. coli is compared to indole signaling, showing opposite effects on biofilm formation and virulence.
Autoinducer 2 (AI-2) is a ubiquitous metabolite but, instead of acting as a universal signal, relatively few phenotypes have been associated with it, and many scientists believe AI-2 is often a metabolic byproduct rather than a signal. Here, the aim is to present evidence that AI-2 influences both biofilm formation and motility (swarming and chemotaxis), using Escherichia coli as the model system, to establish AI-2 as a true signal with an important physiological role in this bacterium. In addition, AI-2 signaling is compared to the other primary signal of E. coli, indole, and it is shown that they have opposite effects on biofilm formation and virulence.
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