期刊
BIOMOLECULES
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biom11020304
关键词
microRNA; cancer therapy; PTEN; lung cancer; breast cancer; long non-coding RNA; circular RNA
资金
- Singapore Ministry of Education [T2EP30120-0042]
- National Research Foundation Singapore
- Singapore Ministry of Education under its Research Centre's of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore
miRNAs play vital roles in breast and lung cancer by regulating the PTEN signaling pathway. The dysregulation of miRNAs in breast and lung cancers is associated with the malignant behavior of tumors.
MicroRNAs (miRNAs) are well-known regulators of biological mechanisms with a small size of 19-24 nucleotides and a single-stranded structure. miRNA dysregulation occurs in cancer progression. miRNAs can function as tumor-suppressing or tumor-promoting factors in cancer via regulating molecular pathways. Breast and lung cancers are two malignant thoracic tumors in which the abnormal expression of miRNAs plays a significant role in their development. Phosphatase and tensin homolog (PTEN) is a tumor-suppressor factor that is capable of suppressing the growth, viability, and metastasis of cancer cells via downregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling. PTEN downregulation occurs in lung and breast cancers to promote PI3K/Akt expression, leading to uncontrolled proliferation, metastasis, and their resistance to chemotherapy and radiotherapy. miRNAs as upstream mediators of PTEN can dually induce/inhibit PTEN signaling in affecting the malignant behavior of lung and breast cancer cells. Furthermore, long non-coding RNAs and circular RNAs can regulate the miRNA/PTEN axis in lung and breast cancer cells. It seems that anti-tumor compounds such as baicalein, propofol, and curcumin can induce PTEN upregulation by affecting miRNAs in suppressing breast and lung cancer progression. These topics are discussed in the current review with a focus on molecular pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据