期刊
BIOMOLECULES
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biom11020249
关键词
non-coding RNA; microRNA; exosomes; cancer; blood vessels; lymphatic vessels
资金
- National Health and Medical Research Council of Australia (NHMRC) [APP1053535, APP1154746, APP1176732]
- Victorian Government
- NHMRC [APP1053535, APP1183926]
Non-coding RNAs play crucial roles in regulating tumor angiogenesis and lymphangiogenesis, as they can be delivered to endothelial cells through exosomes to promote tumor metastasis and progression. These molecules have the potential to serve as cancer biomarkers and may offer opportunities for cancer therapy.
Tumour angiogenesis and lymphangiogenesis are hallmarks of cancer and have been associated with tumour progression, tumour metastasis and poor patient prognosis. Many factors regulate angiogenesis and lymphangiogenesis in cancer including non-coding RNAs which are a category of RNAs that do not encode proteins and have important regulatory functions at transcriptional and post-transcriptional levels. Non-coding RNAs can be encapsulated in extracellular vesicles called exosomes which are secreted by tumour cells or other cells in the tumour microenvironment and can then be taken up by the endothelial cells of blood vessels and lymphatic vessels. The delivery of these non-coding RNAs to endothelial cells in tumours can facilitate tumour angiogenesis and lymphangiogenesis. Here we review recent findings about exosomal non-coding RNAs, specifically microRNAs and long non-coding RNAs, which regulate tumour angiogenesis and lymphangiogenesis in cancer. We then focus on the potential use of these molecules as cancer biomarkers and opportunities for exploiting ncRNAs for the treatment of cancer.
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