Protein Export via the Type III Secretion System of the Bacterial Flagellum

The bacterial flagellum and the related virulence-associated injectisome system of pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins across the inner membrane in a proton motive force-dependent manner. The T3SS is composed of an export gate (FliPQR/FlhA/FlhB) located in the flagellar basal body and an associated soluble ATPase complex in the cytoplasm (FliHIJ). Here, we summarise recent insights into the structure, assembly and protein secretion mechanisms of the T3SS with a focus on energy transduction and protein transport across the cytoplasmic membrane.

Automated summary

The T3SS utilizes proton motive force to export substrate proteins across the inner membrane of pathogenic bacteria. It consists of an export gate and a soluble ATPase complex in the cytoplasm. Recent research on T3SS focuses on energy transduction and protein transport across the cytoplasmic membrane.