期刊
BIOMOLECULES
卷 11, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biom11020212
关键词
RhoA; DNA damage response; cell cycle arrest; DNA repair; Rac1; Net1; Ect2
RhoA plays a crucial role in DNA damage response by interacting with key components of DNA repair and cell cycle control. Understanding the role of RhoA in DDR can provide insights into DDR mechanisms and aid in the development of cancer therapies in the future.
Accumulating evidence has suggested a role of the small GTPase Ras homolog gene family member A (RhoA) in DNA damage response (DDR) in addition to its traditional function of regulating cell morphology. In DDR, 2 key components of DNA repair, ataxia telangiectasia-mutated (ATM) and flap structure-specific endonuclease 1 (FEN1), along with intracellular reactive oxygen species (ROS) have been shown to regulate RhoA activation. In addition, Rho-specific guanine exchange factors (GEFs), neuroepithelial transforming gene 1 (Net1) and epithelial cell transforming sequence 2 (Ect2), have specific functions in DDR, and they also participate in Ras-related C3 botulinum toxin substrate 1 (Rac1)/RhoA interaction, a process which is largely unappreciated yet possibly of significance in DDR. Downstream of RhoA, current evidence has highlighted its role in mediating cell cycle arrest, which is an important step in DNA repair. Unraveling the mechanism by which RhoA modulates DDR may provide more insight into DDR itself and may aid in the future development of cancer therapies.
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