期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 50, 期 16, 页码 8849-8857出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.6b01441
关键词
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资金
- Development of Techniques for Assessment and Management of Hazardous Chemicals in the Marine Environment of the Ministry of Oceans and Fisheries, Kore [20150342]
- Korea-Polar Ocean Development: K-POD of the Ministry of Oceans and Fisheries, Korea [PM15050]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [201403422] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [21A20151313046, 22A20130012056] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In this study, we evaluated accumulation and adverse effects of ingestion of microplastics in the monogonont rotifer (Brachionus koreanus). The dependence of microplastic toxicity on particle size-was investigated by measuring several in vivo end points and studying the ingestion and egestion using 0.05-, 0.5-, and 6-mu m nonfunctionalized polystyrene microbeads. To identify the defense mechanisms activated in response to microplastic exposure, the activities of several antioxidant-related enzymes and the phosphorylation status of mitogen-activated protein kinases (MAPKs) were determined. Exposure to polystyrene microbeads of all sizes led to significant size dependent effects, including reduced groWth rate, reduced fecundity, decreased lifespan and longer reproduction time. Rotifers exposed to 6-mu m fluorescently labeled microbeads exhibited almost no fluorescence after 24 h, while rotifers exposed to 0.05- and 0.5-mu m fluoresceatly labeled inicrobeads displayed fluorescence until 48 h, suggesting that 6-mu m microbeads are more effectively egested from B. koreanus than 0.05- or 0.5-mu m microbeads. This observation provides a potential explanation for our findings that microbead toxicity was size dependent and smaller microbeads were more toxic. In vitro tests revealed that antioxidant-related enzymes and MAPK signaling pathways were significantly activated in response to microplastic exposure in a size-dependent manner.
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