4.7 Review

Advances in Engineering Human Tissue Models

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Summary: PDMS is commonly used in organ-on-a-chip devices and microphysiological systems due to its ease-of-use, elasticity, and optical transparency, but its limitations in the absorption of small molecules and high-throughput manufacturing have led researchers to explore alternative materials such as elastomers, hydrogels, and thermoplastic polymers. The development of organ-on-a-chip devices based on these alternative materials is trending, with researchers focusing on overcoming obstacles to create versatile devices for personalized medicine and drug discovery.

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