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Tropoelastin and Elastin Assembly

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Summary: This study identifies novel cell-adhesive sites in the tropoelastin N-terminal region between domains 12 and 16, which interact with alpha V and alpha 5 beta 1 integrin receptors to facilitate cell attachment and spreading. The findings suggest that domains 12-16 of tropoelastin direct initial cell attachment through cell-surface heparan sulfate glycosaminoglycans, followed by integrin-promoted attachment and spreading, advancing our understanding of elastin matrix biology.

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