期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.629522
关键词
IP3Rs; calcium; endoplasmic reticulum; mitochondria; lysosome; metabolism; inositol triphosphate (IP3) receptors
资金
- ANID/FONDECYT [1200255]
- ANID/FONDAP [15150012]
Recent studies have shown that cross-organelle communication plays a significant role in metabolism, with calcium ions playing a crucial role in this process, especially in cancer.
In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer.
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