4.7 Article

Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability

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Summary: Adaptation to different forms of environmental stress is crucial for maintaining cellular functions and survival, with nucleolus playing a decisive role as a signaling hub; SIRT7 is an essential component for regulating p53 stability during stress responses induced by UV irradiation; Through ATR-mediated phosphorylation, SIRT7 promotes deacetylation of NPM, affecting ubiquitination and stabilization of p53 in response to genotoxic stress.

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