期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.616551
关键词
zebrafish model; tumor visualization; pharmacokinetics; tumor microenvironment; tumor model
资金
- Science and Technology Commission of Shanghai [19JC1410200]
- National Natural Science Foundation of China [81770961, 82073889]
Zebrafish are widely used in cancer research due to their low cost, quick establishment, and small sample size required. The zebrafish patient-derived xenograft (zPDX) models show promising evidence for short-term clinical treatment.
As a promising in vivo tool for cancer research, zebrafish have been widely applied in various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for cancer research that can be established quickly and requires only a small sample size, which makes it favorite among researchers. Zebrafish patient-derived xenograft (zPDX) models provide promising evidence for short-term clinical treatment. In this review, we discuss the characteristics and advantages of zebrafish, such as their transparent and translucent features, the use of vascular fluorescence imaging, the establishment of metastatic and intracranial orthotopic models, individual pharmacokinetics measurements, and tumor microenvironment. Furthermore, we introduce how these characteristics and advantages are applied other in tumor studies. Finally, we discuss the future direction of the use of zebrafish in tumor studies and provide new ideas for the application of it.
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