期刊
PROCESSES
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/pr9030470
关键词
drug carriers; drug delivery; nanoparticles; nanocapsules; liposomes; niosomes; hydrogels; aerogels; quantum dots; dendrimers
This work provides a detailed description of the world of drug carriers, including market revenue, conventional and innovative drug carrier systems, administration routes analysis, drug release kinetics evaluation, carrier classification, therapeutic window concept, and criticism of production techniques by industrial companies. It also emphasizes the necessity of a strong link between versatile drug carrier demands for human applications and newly developed industrial processes.
This work is aimed at providing a description of the complex world of drug carriers, starting from the description of this particular market in terms of revenue. Then, a brief overview of several types of conventional and innovative drug carrier systems has been included. The types of administration routes were also analyzed, with a critical and qualitative comment on drug release kinetics and drug profile shapes. Carriers were classified according to their ability to provide a prolonged and targeted release. The concept of the therapeutic window has been presented, providing advantages of having pulsed drug release to avoid side effects to target tissues. A critical comment on the use of conventional and innovative techniques for the production of drug carriers by large industrial companies has been proposed. As a final attempt for this work, an overall unique schematization of a drug carrier production process has been added, highlighting the necessity to create a strong double link among world-requested versatility of drug carriers for human applications and the newly developed industrial processes.
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