期刊
PHARMACEUTICS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13020273
关键词
mucoadhesion; buccal films; gelatin; propranolol hydrochloride; in silico simulation
资金
- Ministry of Education, Science and Technological Development, Republic of Serbia [451-03-68/2020-14/200135, 451-03-68/2020-14/200161]
This study processed and characterized propranolol hydrochloride/gelatin mucoadhesive buccal films, finding that type A gelatin formed a physical mixture in the film, whereas type B gelatin formed a compound. Mechanical testing results showed that type A gelatin films had higher elastic modulus, tensile strength, and hardness. In terms of adhesion, type B gelatin exhibited higher adhesion strength, while type A gelatin showed higher work of adhesion.
This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets-indicating that the therapeutic drug dose can be markedly reduced.
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