期刊
PHARMACEUTICS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13020218
关键词
ciprofloxacin; ionic liquids; mesoporous silica nanoparticles; cytotoxicity; antimicrobial activity
资金
- FundacAo para a Ciencia e Tecnologia [PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012]
- MAR2020 [MAR-02.01.01-FEAMP-0042-INOVA4AQUA]
- FEDER through COMPETE 2020, POCI and PORL [022161]
- FCT through PIDDAC [022161]
- Fundação para a Ciência e a Tecnologia [PTDC/QUI-QOR/32406/2017] Funding Source: FCT
In this study, two nanomaterials based on mesoporous silica nanoparticles immobilized with ciprofloxacin were prepared and characterized for their structures and antimicrobial activities. The nanomaterials showed promising antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae, with higher activity than the precursor and neutral ciprofloxacin.
Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution H-1 NMR spectroscopies, elemental analysis, XRD and N-2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanomaterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.
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