相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。An overview and metanalysis of machine and deep learning-based CRISPR gRNA design tools
Jun Wang et al.
RNA BIOLOGY (2020)
Evaluation of off-targets predicted by sgRNA design tools
Jaspreet Kaur Dhanjal et al.
GENOMICS (2020)
CRISPR-Net: A Recurrent Convolutional Network Quantifies CRISPR Off-Target Activities with Mismatches and Indels
Jiecong Lin et al.
ADVANCED SCIENCE (2020)
Prediction of the sequence-specific cleavage activity of Cas9 variants
Nahye Kim et al.
NATURE BIOTECHNOLOGY (2020)
Data imbalance in CRISPR off-target prediction
Yuli Gao et al.
BRIEFINGS IN BIOINFORMATICS (2020)
ACME: pan-specific peptide-MHC class I binding prediction through attention-based deep neural networks
Yan Hu et al.
BIOINFORMATICS (2019)
Comprehensive evaluation of deep learning architectures for prediction of DNA/RNA sequence binding specificities
Ameni Trabelsi et al.
BIOINFORMATICS (2019)
Prediction of activity and specificity of CRISPR-Cpf1 using convolutional deep learning neural networks
Jiesi Luo et al.
BMC BIOINFORMATICS (2019)
Prediction of sgRNA on-target activity in bacteria by deep learning
Lei Wang et al.
BMC BIOINFORMATICS (2019)
Prediction of off-target specificity and cell-specific fitness of CRISPR-Cas System using attention boosted deep learning and network-based gene feature
Qiao Liu et al.
PLOS COMPUTATIONAL BIOLOGY (2019)
SpCas9 activity prediction by DeepSpCas9, a deep learning-based model with high generalization performance
Hui Kwon Kim et al.
SCIENCE ADVANCES (2019)
Prediction of CRISPR sgRNA Activity Using a Deep Convolutional Neural Network
Li Xue et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Target-Specific Precision of CRISPR-Mediated Genome Editing
Anob M. Chakrabarti et al.
MOLECULAR CELL (2019)
DeepFam: deep learning based alignment-free method for protein family modeling and prediction
Seokjun Seo et al.
BIOINFORMATICS (2018)
Off-target predictions in CRISPR-Cas9 gene editing using deep learning
Jiecong Lin et al.
BIOINFORMATICS (2018)
Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion
Jia Shou et al.
MOLECULAR CELL (2018)
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response
Emma Haapaniemi et al.
NATURE MEDICINE (2018)
CRISPR/Cas9 cleavages in budding yeast reveal templated insertions and strand-specific insertion/deletion profiles
Brenda R. Lemos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
Jennifer Listgarten et al.
NATURE BIOMEDICAL ENGINEERING (2018)
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
Johnny H. Hu et al.
NATURE (2018)
Engineered CRISPR-Cas9 nuclease with expanded targeting space
Hiroshi Nishimasu et al.
SCIENCE (2018)
Directed evolution of CRISPR-Cas9 to increase its specificity
Jungjoon K. Lee et al.
NATURE COMMUNICATIONS (2018)
DeepCRISPR: optimized CRISPR guide RNA design by deep learning
Guohui Chuai et al.
GENOME BIOLOGY (2018)
Classification of osteoporosis by artificial neural network based on monarch butterfly optimisation algorithm
D. Devikanniga et al.
HEALTHCARE TECHNOLOGY LETTERS (2018)
In vivo high-throughput profiling of CRISPR-Cpf1 activity
Hui K. Kim et al.
NATURE METHODS (2017)
sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity
Raj Chari et al.
ACS SYNTHETIC BIOLOGY (2017)
A machine learning approach for predicting CRISPR-Cas9 cleavage efficiencies and patterns underlying its mechanism of action
Shiran Abadi et al.
PLOS COMPUTATIONAL BIOLOGY (2017)
Analysis of Ribosome Stalling and Translation Elongation Dynamics by Deep Learning
Sai Zhang et al.
CELL SYSTEMS (2017)
Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq
Daesik Kim et al.
GENOME RESEARCH (2016)
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
John G. Doench et al.
NATURE BIOTECHNOLOGY (2016)
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
Maximilian Haeussler et al.
GENOME BIOLOGY (2016)
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran et al.
NATURE (2015)
Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
Babak Alipanahi et al.
NATURE BIOTECHNOLOGY (2015)
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
Xiaoling Wang et al.
NATURE BIOTECHNOLOGY (2015)
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
Miguel A. Moreno-Mateos et al.
NATURE METHODS (2015)
Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach
Raj Chari et al.
NATURE METHODS (2015)
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
Daesik Kim et al.
NATURE METHODS (2015)
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
Henriette O'Geen et al.
NUCLEIC ACIDS RESEARCH (2015)
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2015)
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
Richard L. Frock et al.
NATURE BIOTECHNOLOGY (2015)
Development and Applications of CRISPR-Cas9 for Genome Engineering
Patrick D. Hsu et al.
CELL (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
Cem Kuscu et al.
NATURE BIOTECHNOLOGY (2014)
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
Yanni Lin et al.
NUCLEIC ACIDS RESEARCH (2014)
The new frontier of genome engineering with CRISPR-Cas9
Jennifer A. Doudna et al.
SCIENCE (2014)
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu et al.
NATURE BIOTECHNOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Wenyan Jiang et al.
NATURE BIOTECHNOLOGY (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Fast gapped-read alignment with Bowtie 2
Ben Langmead et al.
NATURE METHODS (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
WebLogo: A sequence logo generator
GE Crooks et al.
GENOME RESEARCH (2004)